How Does Kratom Affect The Body?

Have you ever wondered how Kratom impacts your body? Well, look no further! In this article, we will explore the fascinating effects that Kratom has on your body. From its unique alkaloids to its potential benefits, you’ll discover everything you need to know about this natural supplement. So sit back, relax, and let’s dive into the world of Kratom and its impact on your body!

How Does Kratom Affect The Body?

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What is Kratom?

Kratom, scientifically known as Mitragyna speciosa, is a tropical evergreen tree native to Southeast Asia. It belongs to the coffee family and has been traditionally used for centuries in countries like Thailand, Malaysia, and Indonesia as a medicinal herb. Kratom leaves contain various active compounds, particularly alkaloids, that produce a range of effects on the central nervous system when consumed.

Method of consumption

Kratom can be consumed in different forms depending on personal preferences and desired effects. Some common methods of consumption include:

Powdered form

One of the most popular methods is consuming kratom in its powdered form. The leaves are dried and ground into a fine powder, which can be mixed with water, juice, or added to foods. This method allows for easy and convenient consumption.


For those who prefer a more convenient and discreet method, kratom is also available in capsule form. The powdered kratom is encapsulated, making it easy to swallow and eliminating the need for measuring and mixing.


Another traditional method of consuming kratom is by brewing it into a tea. The powdered or crushed leaves are steeped in hot water and strained, resulting in a kratom-infused tea. This method may require some preparation but allows for a gentle and soothing consumption experience.


Kratom extracts are highly concentrated forms of kratom that contain a higher percentage of active alkaloids. These extracts are typically available in liquid or powder form and require a smaller dosage for the desired effects. However, due to their potency, extracts should be used with caution.

Chewing the leaves

In the regions where kratom grows naturally, chewing the fresh leaves is a common method of consumption. The leaves are chewed, releasing the active compounds, and then spit out. This method provides a more immediate and intense effect, but it is not widely practiced outside of Southeast Asia.

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The active compounds in Kratom

Kratom contains numerous active compounds, including alkaloids, which are responsible for its effects on the central nervous system. The primary alkaloids found in kratom are:


Mitragynine is the most abundant alkaloid in kratom and is believed to be responsible for its pain-relieving and stimulating effects. It interacts with opioid receptors in the brain, producing analgesic and energizing effects. Mitragynine also has potential antinociceptive and anti-inflammatory properties.


7-hydroxymitragynine is another important alkaloid in kratom, though it is present in lower concentrations than mitragynine. It is considered to be a potent opioid agonist and is responsible for kratom’s sedative and analgesic effects. This alkaloid has a higher affinity for mu-opioid receptors, making it highly effective for pain management.


Mitraphylline is a non-opioid alkaloid found in kratom that has been shown to have anti-inflammatory and vasodilatory effects. It may also contribute to the immune-modulating properties of kratom.

Other alkaloids

Kratom contains many other alkaloids, such as speciociliatine, speciogynine, and paynantheine, that contribute to the overall effects of the plant. While their specific mechanisms of action are not fully understood, they may play a role in kratom’s diverse range of therapeutic effects.

Effects on the central nervous system

When consumed, kratom interacts with various receptors in the central nervous system, leading to a range of effects. Some of the most notable effects include:

Pain relief

One of the primary reasons people turn to kratom is for its analgesic properties. The alkaloids in kratom, particularly mitragynine and 7-hydroxymitragynine, interact with the mu-opioid receptors in the brain, producing pain-relieving effects. This can be beneficial for individuals suffering from chronic pain conditions.


Kratom is also known for its stimulating effects, which can provide an energy boost and increase focus and alertness. This stimulating effect is primarily attributed to the mitragynine content in kratom.


On the other end of the spectrum, kratom can also have sedating effects, particularly when consumed in higher doses. The 7-hydroxymitragynine alkaloid has a higher affinity for the mu-opioid receptors, producing a calming and relaxing effect. This sedating effect can be useful for individuals struggling with insomnia or anxiety.

Mood enhancement

Many kratom users report experiencing an improved mood after consuming the plant. This is believed to be due to the interaction of various alkaloids with different receptors in the brain, resulting in an elevation of mood and sense of well-being.

Anxiolytic effects

Kratom has also been reported to have anxiolytic properties, meaning it can help alleviate symptoms of anxiety. The exact mechanisms behind this effect are not completely understood, but it is believed to involve the interaction of alkaloids with the opioid and adrenergic receptors.

How Does Kratom Affect The Body?

Interactions with opioid receptors

Kratom’s effects on the central nervous system are primarily attributed to its interactions with opioid receptors. The three main types of opioid receptors that kratom interacts with are:

Binding to mu-opioid receptors

Mitragynine and 7-hydroxymitragynine, the primary alkaloids in kratom, have a high affinity for mu-opioid receptors. These receptors are involved in pain regulation, and their activation by kratom’s alkaloids produces analgesic effects.

Activation of delta-opioid receptors

Kratom also interacts with delta-opioid receptors, although to a lesser extent than mu-opioid receptors. These receptors are believed to play a role in mood enhancement and stress reduction. By activating delta-opioid receptors, kratom may contribute to its mood-enhancing effects.

Interaction with kappa-opioid receptors

Kratom’s alkaloids also interact with kappa-opioid receptors, although the exact mechanisms and effects are not yet fully understood. Activation of kappa-opioid receptors has been associated with dysphoria and sedation, suggesting that these interactions may contribute to the sedative effects of kratom.

Metabolism and pharmacokinetics

Understanding the metabolism and pharmacokinetics of kratom is crucial for determining its effects and potential therapeutic uses. Here is a brief overview of the key aspects:


Kratom is primarily absorbed through the gastrointestinal tract when consumed orally. The active compounds are dissolved in the stomach and intestines, absorbed into the bloodstream, and then distributed to various tissues.


Once absorbed, kratom’s alkaloids are distributed throughout the body. They can cross the blood-brain barrier, allowing them to interact with receptors in the central nervous system and produce their effects.


Kratom undergoes extensive metabolism in the liver, primarily through the action of enzymes such as CYP3A4 and CYP2D6. These enzymes convert the active alkaloids into metabolites, which are then eliminated from the body.


The metabolites of kratom are mainly eliminated through urine and feces. The elimination half-life, which is the time taken for half of the substance to be eliminated from the body, can vary depending on individual factors and the specific alkaloids in kratom.


The half-life of kratom’s alkaloids can range from several hours to a day. This means that the effects of kratom can last for several hours, and the duration may vary depending on the dosage and method of consumption.

How Does Kratom Affect The Body?

Potential therapeutic uses of Kratom

Kratom has gained attention for its potential therapeutic uses in various medical conditions. Some of the potential therapeutic uses of kratom include:

Pain management

The analgesic properties of kratom make it a potential alternative for individuals suffering from chronic pain. Kratom’s interaction with mu-opioid receptors produces pain relief without the risk of respiratory depression associated with traditional opioids.

Management of opioid withdrawal symptoms

Due to its interactions with opioid receptors, kratom may also have potential in managing opioid withdrawal symptoms. Some individuals have reported using kratom to ease the withdrawal symptoms associated with opioid dependence, although more research is needed to determine its efficacy and safety.

Boosting mood and wellbeing

Kratom’s mood-enhancing effects make it a potential tool for managing mood-related disorders such as depression and anxiety. The alkaloids in kratom may help elevate mood and provide a sense of well-being, although further research is needed to fully understand its mechanisms and potential applications.

Managing anxiety and depression

Kratom’s anxiolytic effects may offer relief for individuals suffering from anxiety and depression. Its interaction with opioid and adrenergic receptors may help regulate mood and reduce symptoms of these mental health conditions.

Adverse effects and risks

While kratom may offer potential therapeutic benefits, it is essential to consider the potential risks and adverse effects associated with its consumption. Some of the potential adverse effects of kratom include:

Nausea and vomiting

Nausea and vomiting are common side effects of consuming kratom, particularly at higher doses. These effects are usually short-lived and resolve on their own.


Kratom can also cause constipation, as it slows down intestinal motility. This is due to its interactions with opioid receptors in the gastrointestinal tract.

Dizziness and lethargy

In higher doses, kratom can cause dizziness and lethargy. These effects are typically dose-dependent and may vary among individuals.

Liver toxicity

There have been rare reports of liver toxicity associated with kratom consumption. However, the exact mechanisms and risk factors are not yet fully understood, and more research is needed to determine the extent of this potential risk.

Addiction and dependence

Kratom has the potential for abuse and dependence, particularly when used in high doses or over a prolonged period. Regular and excessive kratom use can lead to physical and psychological dependence and withdrawal symptoms upon cessation.

Respiratory depression

While kratom’s interactions with opioid receptors do not typically lead to respiratory depression, high doses of kratom may produce this effect. It is important to exercise caution and avoid excessive doses to minimize the risk of respiratory depression.

How Does Kratom Affect The Body?

Legality and regulatory status

The legal status of kratom varies from country to country, and even within different regions of the same country. For example, in the United States, kratom is federally legal at the moment, but certain states have implemented their own regulations or bans on kratom. It is important to be aware of the legal status and regulations surrounding kratom in your specific location.

FDA warnings and regulations

The U.S. Food and Drug Administration (FDA) has expressed concerns about the safety and potential risks associated with kratom use. In 2014, the FDA issued an import alert, making it difficult for kratom products to enter the country. The FDA has also warned against the use of kratom due to the potential for addiction, abuse, and other adverse effects.

Quality control and product safety

Due to the increasing popularity of kratom, there have been concerns regarding the quality and safety of kratom products. Some manufacturers may not adhere to strict quality control standards, leading to variations in the potency and purity of kratom products. It is important to source kratom products from reputable vendors who prioritize quality assurance and product safety.

Research gaps and limitations

While there is growing interest in kratom and its potential therapeutic uses, there are still several research gaps and limitations that need to be addressed. Some key areas of concern include:

Limited clinical studies

There is a lack of well-controlled clinical studies investigating the effects, safety, and potential therapeutic applications of kratom. Most of the available research comes from animal studies and anecdotal reports, highlighting the need for more comprehensive and rigorous research.

Lack of standardized dosing guidelines

Another challenge in kratom research is the absence of standardized dosing guidelines. The optimal dosage of kratom may vary depending on individual factors, the specific alkaloid content, and the desired effects. Establishing standardized dosing guidelines is crucial for ensuring safety and consistency in kratom consumption.

Ethical concerns around research on Kratom

Due to the controversy surrounding kratom and its potential risks, there may be ethical concerns around conducting research on this plant. Researchers need to navigate the regulatory landscape and address potential biases when designing studies and interpreting the results.

In conclusion, kratom is a plant with a long history of traditional use and potential therapeutic value. Its active alkaloids interact with opioid receptors, producing a range of effects on the central nervous system. However, it is important to consider the potential risks and limitations associated with kratom, including the possibility of adverse effects and the need for further research. If you are considering using kratom for any purpose, it is crucial to consult with a healthcare professional who can provide personalized guidance and ensure your safety.

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